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Article

Diversity training for signal transduction: leveraging cell-to-cell variability to dissect cellular signaling, differentiation and death.

Current opinion in biotechnology - 1 Aug 2013

Cotari Jesse W, Voisinne Guillaume, Altan-Bonnet Grégoire

Abstract excerpt

Populations of 'identical' cells are rarely truly identical. Even when in the same state of differentiation, isogenic cells may vary in expression of key signaling regulators, activate signal transduction at different thresholds, and consequently respond heterogeneously to a given stimulus. Here, we review how new experimental and analytical techniques are suited to connect these different levels of variability,...

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Identifiers

PMID: 23747193
DOI: 10.1016/j.copbio.2013.05.002
PMCID: PMC3863640

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