Variation is function: Are single cell differences functionally important?: Testing the hypothesis that single cell variation is required for aggregate function.

Abstract excerpt

There is a growing appreciation of the extent of transcriptome variation across individual cells of the same cell type. While expression variation may be a byproduct of, for example, dynamic or homeostatic processes, here we consider whether single-cell molecular variation per se might be crucial for population-level function. Under this hypothesis, molecular variation indicates a diversity of hidden functional...

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