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Article

Epigenetic modulations rendering cell-to-cell variability and phenotypic metastability.

Journal of genetics and genomics = Yi chuan xue bao - 20 Aug 2016

Spencer Shawal, Gugliotta Agustina, Gödecke Natascha, Hauser Hansjörg, Wirth Dagmar

Abstract excerpt

Tumor cells display phenotypic plasticity and heterogeneity due to genetic and epigenetic variations which limit the predictability of therapeutic interventions. Chromatin modifications can arise stochastically but can also be a consequence of environmental influences such as the microenvironment of cancer cells. A better understanding of the impact and dynamics of epigenetic modulation at defined chromosomal...

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Identifiers

PMID: 27569397
DOI: 10.1016/j.jgg.2016.05.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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