Article

Histone hyperacetylation-linked upregulation of KRAB zinc finger proteins impedes glial differentiation in Huntington’s disease

2025-12-02

Abstract excerpt

Glial differentiation is impaired in Huntington disease (HD), contributing to both the synaptic dysfunction and hypomyelination of HD. Through combined epigenomic and transcriptomic profiling, we found that glial progenitor cells (hGPCs) generated from HD-derived human embryonic stem cells exhibit persistent histone hyperacetylation, enabling the ectopic expression of a broad set of KRAB zinc finger protein (KZFP)...

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Literature Corpus work: 7cd15cc6-6b4b-5b9c-9df8-2392808a743e
DOI: 10.64898/2025.11.30.691437

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