Article

Dynamic play between human N-α-acetyltransferase D and H4-mutant histones: Molecular dynamics study

2022-03-18

Abstract excerpt

<h4>ABSTRACT</h4> N-terminal acetyltransferases (NATs) are overexpressed in various cancers. Specifically in lung cancer, human N-α-acetyltransferase D (hNatD) is upregulated and prevents the histone H4 N-terminal serine phosphorylation, leading to the epithelial-to-mesenchymal transition (EMT) of cancer cells. hNatD facilitates histone H4 N-α-terminal serine acetylation and halts the CK2α-mediated serine phospho...

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Literature Corpus work: 7c9a8f5e-b25c-55b5-a3b4-5daef2285ae6
DOI: 10.1101/2022.03.15.484466

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