Article

Alignment of human KAT2A (GCN5) Histone Acetyltransferase and SARS-CoV-2 Orf8 viral proteins

2022-11-14

Abstract excerpt

<title>Abstract</title> <p>Introduction: The SARS-CoV-2 virus has evolved to mimic an enzyme, KAT2A (lysine acetyltransferase 2A, GCN5), one of the histone proteins that package DNA in the cell nucleus. Gene transcription is deranged because of this mimicry, which reduces antiviral response. An amino acid sequence known as the ARKS motif in histone H3 is modified by KAT2A, which adds acetyl groups and encourages...

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Literature Corpus work: 3ff80797-8834-583b-91bc-96349c7b8b04
DOI: 10.21203/rs.3.rs-2235254/v2

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