Article

The oncogenic CCDC6-RET fusion product is a dual ATP and ADP-dependent kinase that functions via <i>cis</i> -phosphorylation

2025-01-16

Abstract excerpt

<h4>Summary</h4> Gene fusions products involving protein kinases are known drivers in human cancers and actionable targets for personalized therapy, yet the structural and molecular determinants that control their function are largely unexplored. Here we show that a CCDC6-RET fusion product, a driver and therapeutic target in lung and thyroid cancers, is a highly active dimeric kinase in solution. Time-resolved m...

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Literature Corpus work: 2217c037-f1e3-5adb-8664-6d82732eb823
DOI: 10.1101/2025.01.14.632894

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