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Article

Correlated Motions and Dynamics in Different Domains of Epidermal Growth Factor Receptor With L858R and T790M Mutations.

IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000

Qureshi Rizwan, Ghosh Avirup, Yan Hong

Abstract excerpt

Non-small cell lung cancer with an activating epidermal growth factor receptor (EGFR) mutation responds well to targeted drugs. In most cases, drug resistance appears after about a year. Several studies have been conducted on the kinase domain of EGFR to understand the drug resistance mechanism. Since EGFR is a multi-domain protein, mutation in the kinase domain may affect the other domains as well. In this...

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PMID: 32750848
DOI: 10.1109/TCBB.2020.2995569

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