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Article

Effects of single nucleotide polymorphisms on human N-acetyltransferase 2 structure and dynamics by molecular dynamics simulation.

PloS one - 1 Jan 2011

Rajasekaran M, Abirami Santhanam, Chen Chinpan

Abstract excerpt

BACKGROUND: Arylamine N-acetyltransferase 2 (NAT2) is an important catalytic enzyme that metabolizes the carcinogenic arylamines, hydrazine drugs and chemicals. This enzyme is highly polymorphic in different human populations. Several polymorphisms of NAT2, including the single amino acid substitutions R64Q, I114T, D122N, L137F, Q145P, R197Q, and G286E, are classified as slow acetylators, whereas the wild-type...

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Identifiers

PMID: 21980537
DOI: 10.1371/journal.pone.0025801
PMCID: PMC3183086

Genes

NAT2

Variants

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Source receipt: pubmed, retrieved 7 Sept 2026.

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