Article
A novel genetic screen implicates Elm1 in the inactivation of the yeast transcription factor SBF.
PloS one - 30 Jan 2008
Manderson Emily N, Malleshaiah Mohan, Michnick Stephen W
Abstract excerpt
BACKGROUND: Despite extensive large scale analyses of expression and protein-protein interactions (PPI) in the model organism Saccharomyces cerevisiae, over a thousand yeast genes remain uncharacterized. We have developed a novel strategy in yeast that directly combines genetics with proteomics in the same screen to assign function to proteins based on the observation of genetic perturbations of sentinel protein...
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