Back to search

Article

Multi-disease associated risk locus in <i>IL6</i> represses the anti-inflammatory gene <i>GPNMB</i> through chromatin looping and recruiting MEF2-HDAC complex

2019-04-09

Abstract excerpt

We have previously revealed a genetic association between Takayasu arteritis and a non-coding genetic variant in an enhancer region within IL6 (rs2069837 A/G). The risk allele in this variant (allele A) has a protective effect against chronic viral infection and cancer. Using a combination of experimental and bioinformatics tools, we identified the monocyte/macrophage anti-inflammatory gene GPNMB , ∼520kb away,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7c89fb4d-95c2-5cc6-a157-addf1db9b6e9
DOI
10.1101/602797
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Multi-disease associated risk locus in <i>IL6</i> represses the anti-inflammatory gene <i>GPNMB</i> through chromatin looping and recruiting MEF2-HDAC complexDOI 10.1101/602797
Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study.Semantic proximity
Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.Semantic proximity
The genetics of Takayasu arteritis.Semantic proximity
Immunoregulatory gene <i>GIMAP6</i> suppresses lethal atherosclerotic vasculopathy and ischemic heart failureSemantic proximity
Identification of multiple genetic susceptibility loci in Takayasu arteritis.Semantic proximity
Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population.Semantic proximity
Genetically downregulated interleukin-6 signaling is associated with a favorable cardiometabolic profile: a phenome-wide association studySemantic proximity
Human genetic evidence to inform clinical development of interleukin-6 signaling inhibition for abdominal aortic aneurysmSemantic proximity
Single nucleotide polymorphisms of IL12B are associated with Takayasu arteritis in Chinese Han population.Semantic proximity
Functional relevance for multiple sclerosis-associated genetic variants.Semantic proximity
Epigenomic functional characterization of genetic susceptibility variants in systemic vasculitis.Semantic proximity
Identification of key regulatory factors for m6A in myasthenia gravis and characteristics of the immune characteristicsSemantic proximity
Select a neighboring publication to make it the new centre.