Article
Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population.
American journal of human genetics - 8 Aug 2013
Terao Chikashi, Yoshifuji Hajime, Kimura Akinori, Matsumura Takayoshi, Ohmura Koichiro, Takahashi Meiko, Shimizu Masakazu, Kawaguchi Takahisa, Chen Zhiyong, Naruse Taeko K, Sato-Otsubo Aiko, Ebana Yusuke, Maejima Yasuhiro, Kinoshita Hideyuki, Murakami Kosaku, Kawabata Daisuke, Wada Yoko, Narita Ichiei, Tazaki Junichi, Kawaguchi Yasushi, Yamanaka Hisashi, Yurugi Kimiko, Miura Yasuo, Maekawa Taira, Ogawa Seishi, Komuro Issei, Nagai Ryozo, Yamada Ryo, Tabara Yasuharu, Isobe Mitsuaki, Mimori Tsuneyo, Matsuda Fumihiko
Abstract excerpt
Takayasu arteritis (TAK) is an autoimmune systemic vasculitis of unknown etiology. Although previous studies have revealed that HLA-B*52:01 has an effect on TAK susceptibility, no other genetic determinants have been established so far. Here, we performed genome scanning of 167 TAK cases and 663 healthy controls via Illumina Infinium Human Exome BeadChip arrays, followed by a replication study consisting of 212...
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