Article
Identification of multiple genetic susceptibility loci in Takayasu arteritis.
American journal of human genetics - 8 Aug 2013
Saruhan-Direskeneli Güher, Hughes Travis, Aksu Kenan, Keser Gokhan, Coit Patrick, Aydin Sibel Z, Alibaz-Oner Fatma, Kamalı Sevil, Inanc Murat, Carette Simon, Hoffman Gary S, Akar Servet, Onen Fatos, Akkoc Nurullah, Khalidi Nader A, Koening Curry, Karadag Omer, Kiraz Sedat, Langford Carol A, McAlear Carol A, Ozbalkan Zeynep, Ates Askin, Karaaslan Yasar, Maksimowicz-McKinnon Kathleen, Monach Paul A, Ozer Hüseyin T, Seyahi Emire, Fresko Izzet, Cefle Ayse, Seo Philip, Warrington Kenneth J, Ozturk Mehmet A, Ytterberg Steven R, Cobankara Veli, Onat A Mesut, Guthridge Joel M, James Judith A, Tunc Ercan, Duzgun Nurşen, Bıcakcıgil Muge, Yentür Sibel P, Merkel Peter A, Direskeneli Haner, Sawalha Amr H
Abstract excerpt
Takayasu arteritis is a rare inflammatory disease of large arteries. The etiology of Takayasu arteritis remains poorly understood, but genetic contribution to the disease pathogenesis is supported by the genetic association with HLA-B*52. We genotyped ~200,000 genetic variants in two ethnically divergent Takayasu arteritis cohorts from Turkey and North America by using a custom-designed genotyping platform...
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