Article

A conserved mechanism for regulation of endo-lysosomal pH by histone deacetylases

2018-01-22

Abstract excerpt

<h4>ABSTRACT</h4> The pH of the endo-lysosomal system is tightly regulated by a balance of proton pump and leak mechanisms that are critical for storage, recycling, turnover and signaling functions in the cell. Dysregulation of endo-lysosomal pH has been linked to aging, amyloidogenesis, synaptic dysfunction, and various neurodegenerative disorders including Alzheimer’s disease. Therefore, understanding mechanism...

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Literature Corpus work: 7c21466b-99b0-5331-883a-d3b800ab8b0b
DOI: 10.1101/252122

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