Article

The Amyloid Clearance Defect in ApoE4 Astrocytes is Corrected by Epigenetic Restoration of NHE6

2018-01-04

Abstract excerpt

<h4>Summary</h4> The accumulation of amyloid protein Aβ in senile plaques is a key driver and hallmark of Alzheimer disease (AD), a major cause of death and dementia in the elderly. The strongest genetic risk factor in sporadic AD is the ε4 allele of Apolipoprotein E (ApoE4), which potentiates pre-symptomatic endosomal dysfunction and defective clearance of Aβ, although how these two pathways are linked has been...

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Literature Corpus work: 432dac54-9ff9-5715-a2f2-16cc39ee1740
DOI: 10.1101/243097

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