Article

Activation of AKT induces EZH2-mediated β-catenin trimethylation in colorectal cancer

2023-02-03

Abstract excerpt

Colorectal cancer (CRC) develops in part through the deregulation of different signaling pathways, including activation of the WNT/β-catenin and PI3K/AKT pathways. Enhancer of zeste homolog 2 (EZH2) is a lysine methyltransferase that is involved in regulating stem cell development and differentiation and is overexpressed in CRC. However, depending on the study EZH2 has been found to be both positively and negative...

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Literature Corpus work: 7c1020f1-8198-5b16-b68c-139eb0f16d24
DOI: 10.1101/2023.01.31.526429

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