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Article

EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe?

International journal of molecular sciences - 31 May 2017

Yan Ke-Sin, Lin Chia-Yuan, Liao Tan-Wei, Peng Cheng-Ming, Lee Shou-Chun, Liu Yi-Jui, Chan Wing P, Chou Ruey-Hwang

Abstract excerpt

Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery. EZH2 functions as a double-facet molecule in regulation of gene expression via repression or activation mechanisms, depending on the different cellular contexts. EZH2 interacts with both histone and non-histone proteins to modulate...

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Identifiers

PMID: 28561778
DOI: 10.3390/ijms18061172
PMCID: PMC5485996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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