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Article

The polycomb group protein EZH2 induces epithelial–mesenchymal transition and pluripotent phenotype of gastric cancer cells by binding to PTEN promoter

15 Jan 2018

Abstract excerpt

BACKGROUND: The influences of oncogenic Ezh2 on the progression and prognosis of gastric cancer (GC) and the underlying mechanisms are still poorly understood. Here, we aimed at investigating clinicopathological significance of Ezh2 in GC and the mechanisms underlying its function in GC development. METHODS: The expression level of Ezh2 was determined by qRT-PCR, immunoblot, and immunohistochemistry analysis in...

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PMID: 29335012
DOI: 10.1186/s13045-017-0547-3

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