Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT Pathway

9 Mar 2021

Abstract excerpt

Background: The incidence of colorectal cancer (CRC) has been increasing worldwide in recent years. Targeting cancer stem cells (CSCs) in CRC remains a difficult challenge. KDM2B and EZH2 play important role in the maintenance of CSCs' self-renewal capacity and tumorigenic ability; however, the biological functions of those genes in CRC remain unclear. In this study, we aimed to define the contribution of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer-related molecular mechanisms research
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33791221
DOI: 10.3389/fonc.2021.637298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT PathwayPMID 33791221Read ↗

Special AT-rich sequence-binding protein 2 acts as a negative regulator of stemness in colorectal cancer cells.Semantic proximity Read ↗

EZH2 promotes colorectal cancer stem-like cell expansion by activating p21cip1-Wnt/β-catenin signalingSemantic proximity Read ↗

Portrait of Cancer Stem Cells on Colorectal Cancer: Molecular Biomarkers, Signaling Pathways and miRNAomeSemantic proximity Read ↗

Molecular Biomarkers and Signaling Pathways of Cancer Stem Cells in Colorectal CancerSemantic proximity Read ↗

SMOC2, an intestinal stem cell marker, is an independent prognostic marker associated with better survival in colorectal cancers.Semantic proximity Read ↗

EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe?Semantic proximity Read ↗

Comprehensive Analysis and Experimental Validation of HEPACAM2 as a Potential Prognosis Biomarker and Immunotherapy Target in Colorectal CancerSemantic proximity Read ↗

Role of EZH2 in cancer stem cells: from biological insight to a therapeutic targetSemantic proximity Read ↗

EZH2 activates CHK1 signaling to promote ovarian cancer chemoresistance by maintaining the properties of cancer stem cellsSemantic proximity Read ↗

Downregulation of Enhancer of Zeste Homolog 2 (EZH2) is essential for the Induction of Autophagy and Apoptosis in Colorectal Cancer CellsSemantic proximity Read ↗

Mechanisms Underlying Cancer Growth and Apoptosis by DEK Overexpression in Colorectal CancerSemantic proximity Read ↗

Colorectal Cancer Stem Cell Biomarkers: Biological Traits and Prognostic InsightsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.