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Article

Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations.

Cancer research - 1 Feb 2016

Riquelme Erick, Behrens Carmen, Lin Heather Y, Simon George, Papadimitrakopoulou Vassiliki, Izzo Julie, Moran Cesar, Kalhor Neda, Lee J Jack, Minna John D, Wistuba Ignacio I

Abstract excerpt

EZH2 overexpression promotes cancer by increasing histone methylation to silence tumor suppressor genes, but how EZH2 levels become elevated in cancer is not understood. In this study, we investigated the mechanisms by which EZH2 expression is regulated in non-small cell lung carcinoma cells by oncogenic KRAS. In cells harboring KRAS(G12C) and KRAS(G12D) mutations, EZH2 expression was modulated by MEK-ERK and...

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Identifiers

PMID: 26676756
DOI: 10.1158/0008-5472.CAN-15-1141
PMCID: PMC4738155

Genes

KRAS
STAT3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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