Epigenetic and Oncogenic Inhibitors Cooperatively Drive Differentiation and Kill KRAS-Mutant Colorectal Cancers.

doi:10.1158/2159-8290.CD-23-0866

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Article

Epigenetic and Oncogenic Inhibitors Cooperatively Drive Differentiation and Kill KRAS-Mutant Colorectal Cancers.

Cancer discovery - 2 Dec 2024

Loi Patrick, Schade Amy E, Rodriguez Carrie L, Krishnan Anjana, Perurena Naiara, Nguyen Van T M, Xu Yilin, Watanabe Marina, Davis Rachel A, Gardner Alycia, Pilla Natalie F, Mattioli Kaia, Popow Olesja, Gunduz Nuray, Lannagan Tamsin R M, Fitzgerald Samantha, Sicinska Ewa T, Lin Jia-Ren, Tan William, Brais Lauren K, Haigis Kevin M, Giannakis Marios, Ng Kimmie, Santagata Sandro, Helin Kristian, Sansom Owen J, Cichowski Karen

Abstract excerpt

SIGNIFICANCE: Combined EZH2 and RAS pathway inhibitors kill KRAS-mutant colorectal cancer cells and promote durable tumor regression in vivo. These agents function by cooperatively suppressing the WNT pathway, driving differentiation, and epigenetically reprogramming cells to permit the induction of apoptotic signals, which then kill these more differentiated tumor cells.

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Identifiers

PMID: 39121480
DOI: 10.1158/2159-8290.CD-23-0866
PMCID: PMC11609823

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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