Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone-acetyl epigenome regulates TGF-β pathway-associated chemoresistance in colorectal cancer

9 Nov 2024

Abstract excerpt

• The functional implications of the comprehensive epigenetic landscape associated with TGF-β pathway-induced chemoresistance remain unclear in colorectal cancer (CRC). • This study elucidates hyperacetylation of H3K9 and H3K18 through a genome-wide epigenetic modification screening. • Mechanistically, these epigenetic changes are orchestrated by HDAC4, acting as a tumor suppressor to induce chemoresistance in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39522302
DOI: 10.1016/j.tranon.2024.102166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone-acetyl epigenome regulates TGF-β pathway-associated chemoresistance in colorectal cancerPMID 39522302Read ↗

Characterization of TGFβ-Associated Molecular Features and Drug Responses in Gastrointestinal AdenocarcinomaSemantic proximity Read ↗

Hsa-miR-186-5p regulates TGFβ signaling pathway through expression suppression of SMAD6 and SMAD7 genes in colorectal cancerSemantic proximity Read ↗

Regulation of transforming growth factor-β signaling as a therapeutic approach to treating colorectal cancerSemantic proximity Read ↗

HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migrationSemantic proximity Read ↗

Pharmacological modulation of RB1 activity mitigates resistance to neoadjuvant chemotherapy in locally advanced rectal cancerSemantic proximity Read ↗

The TGF‐β/Smad2/3 signaling pathway is involved in Musashi2‐induced invasion and metastasis of colorectal cancerSemantic proximity Read ↗

Histone Deacetylases and their Inhibitors in Colorectal Cancer Therapy: Current Evidence and Future ConsiderationsSemantic proximity Read ↗

Transforming Growth Factor-β Signaling Pathway in Colorectal Cancer and Its Tumor MicroenvironmentSemantic proximity Read ↗

Unraveling <em>TNXB </em>Epigenetic Alterations through Genome wide DNA methylation and their Implications for Colorectal Cancer PathogenesisSemantic proximity Read ↗

Epigenetic regulation of TGF-β and vice versa in cancers – A review on recent developmentsSemantic proximity Read ↗

TGFβ and the Tumor Microenvironment in Colorectal CancerSemantic proximity Read ↗

Loss of p53 epigenetically modulates epithelial to mesenchymal transition in colorectal cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.