Article

CTCF regulates wild-type and recombinant AAV gene expression by shaping viral chromatin

2026-06-03

Abstract excerpt

<h4>ABSTRACT</h4> Adeno-Associated Viruses (AAVs) are powerful platforms for delivering therapeutic transgenes via recombinant AAV (rAAV) vectors. However, a limited understanding of the regulation of AAV gene expression has narrowed the ability to efficiently express therapeutic transgenes from rAAV vectors. Since rAAVs retain only the wtAAV inverted terminal repeats (ITR), we hypothesized that regulatory elemen...

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Literature Corpus work: f79467dc-a1a8-59f1-adbc-0498c91298a7
DOI: 10.64898/2026.06.03.729793

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