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Signal Transducer and Activator of Transcription 4 in Liver Diseases

1 Jan 2015

Abstract excerpt

STAT4 is a member of the signal transducer and activator of transcription (STAT) family of molecules that localizes to the cytoplasm. STAT4 regulates various genes expression as a transcription factor after it is phosphorylated, dimerizes and translocates to the nucleus. STAT4 activation is detected virtually in the liver of several mouse models of liver injury, as well as the human liver of chronic liver...

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PMID: 25798064
DOI: 10.7150/ijbs.11164

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