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Article

Contextual Regulation of TGF-β Signaling in Liver Cancer

11 Oct 2019

Abstract excerpt

Primary liver cancer is one of the leading causes for cancer-related death worldwide. Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that signals through membrane receptors and intracellular Smad proteins, which enter the nucleus upon receptor activation and act as transcription factors. TGF-β inhibits liver tumorigenesis in the early stage by inducing cytostasis and apoptosis, but promotes...

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PMID: 31614569
DOI: 10.3390/cells8101235

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