Article

Biochemical characterizations of ER-resident peroxidases, GPx7 and GPx8, reveal their distinct and regulated oxidative activities

2020-03-27

Abstract excerpt

In the mammalian endoplasmic reticulum (ER), the diverse network comprising more than 20 members of the protein disulfide isomerase (PDI) family and more than five PDI oxidases has evolved to promote oxidative protein folding. While the canonical disulfide bond formation pathway constituted by Ero1α and PDI has been well studied so far, mechanistic and physiological bases of newly identified PDI oxidases, glutathi...

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Literature Corpus work: 7bef2b5d-99c0-562a-9711-0723846f5f1e
DOI: 10.1101/2020.03.26.010116

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