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Article

Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4.

The Biochemical journal - 1 Jan 2012

Wang Xi, Wang Likun, Wang Xi'e, Sun Fei, Wang Chih-chen

Abstract excerpt

Prx4 (peroxiredoxin 4) is the only peroxiredoxin located in the ER (endoplasmic reticulum) and a proposed scavenger for H2O2. In the present study, we solved crystal structures of human Prx4 in three different redox forms and characterized the reaction features of Prx4 with H2O2. Prx4 exhibits a toroid-shaped decamer constructed of five catalytic dimers. Structural analysis revealed conformational changes around...

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Identifiers

PMID: 21916849
DOI: 10.1042/BJ20110380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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