Article
Glutathione is required to regulate the formation of native disulfide bonds within proteins entering the secretory pathway.
The Journal of biological chemistry - 17 Sept 2004
Chakravarthi Seema, Bulleid Neil J
Abstract excerpt
The formation of native disulfide bonds is an essential event in the folding and maturation of proteins entering the secretory pathway. For native disulfides to form efficiently an oxidative pathway is required for disulfide bond formation and a reductive pathway is required to ensure isomerization of non-native disulfide bonds. The oxidative pathway involves the oxidation of substrate proteins by PDI, which in...
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