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Article

Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.

Biochimica et biophysica acta - 1 Jun 2013

Bosello-Travain Valentina, Conrad Marcus, Cozza Giorgio, Negro Alessandro, Quartesan Silvia, Rossetto Monica, Roveri Antonella, Toppo Stefano, Ursini Fulvio, Zaccarin Mattia, Maiorino Matilde

Abstract excerpt

BACKGROUND: Mammalian GPx7 is a monomeric glutathione peroxidase of the endoplasmic reticulum (ER), containing a Cys redox center (CysGPx). Although containing a peroxidatic Cys (CP) it lacks the resolving Cys (CR), that confers fast reactivity with thioredoxin (Trx) or related proteins to most other CysGPxs. METHODS: Reducing substrate specificity and mechanism were addressed by steady-state kinetic analysis of...

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Identifiers

PMID: 23454490
DOI: 10.1016/j.bbagen.2013.02.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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