Article
Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.
Molecular cell - 14 Dec 2012
Wei Pei-Chi, Hsieh Yi-Hsuan, Su Mei-I, Jiang Xianzhi, Hsu Pang-Hung, Lo Wen-Ting, Weng Jui-Yun, Jeng Yung-Ming, Wang Ju-Ming, Chen Phang-lang, Chang Yi-Cheng, Lee Kuo-Fen, Tsai Ming-Daw, Shew Jin-Yuh, Lee Wen-Hwa
Abstract excerpt
NPGPx is a member of the glutathione peroxidase (GPx) family; however, it lacks GPx enzymatic activity due to the absence of a critical selenocysteine residue, rendering its function an enigma. Here, we show that NPGPx is a newly identified stress sensor that transmits oxidative stress signals by forming the disulfide bond between its Cys57 and Cys86 residues. This oxidized form of NPGPx binds to...
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