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Article

Mutations affecting glycinergic neurotransmission in hyperekplexia increase pain sensitivity.

Brain : a journal of neurology - 1 Jan 2018

Vuilleumier Pascal Henri, Fritsche Raphael, Schliessbach Jürg, Schmitt Bernhard, Arendt-Nielsen Lars, Zeilhofer Hanns Ulrich, Curatolo Michele

Abstract excerpt

See Dickenson (doi:10.1093/brain/awx334) for a scientific commentary on this article.Inhibitory interneurons in the spinal cord use glycine and GABA for fast inhibitory neurotransmission. While there is abundant research on these inhibitory pain pathways in animal models, their relevance in humans remains unclear, largely due to the limited possibility to manipulate selectively these pathways in humans....

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Source

Identifiers

PMID: 29149236
DOI: 10.1093/brain/awx289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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