Article

Mutating <i>PINK1</i> gene by paired truncated sgRNA/Cas9-D10A in Cynomolgus Monkey

2020-10-21

Abstract excerpt

Mutations of PINK1 cause early-onset Parkinson’s disease (PD) with selective neurodegeneration in humans. However,current PINK1 knockout mouse and pig models are unable to recapitulate the typical neurodegenerative phenotypes observed in PD patients, indicating that it is essential to generate PINK1 disease models in non-human primates (NHPs) that are highly close to humans, to investigate the unique function o...

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Literature Corpus work: 7e5f0e96-ee51-5db7-8932-8c26b51a60e6
DOI: 10.1101/2020.10.21.348862

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