Article
Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9.
Human molecular genetics - 1 Jul 2015
Chen Yongchang, Zheng Yinghui, Kang Yu, Yang Weili, Niu Yuyu, Guo Xiangyu, Tu Zhuchi, Si Chenyang, Wang Hong, Xing Ruxiao, Pu Xiuqiong, Yang Shang-Hsun, Li Shihua, Ji Weizhi, Li Xiao-Jiang
Abstract excerpt
CRISPR/Cas9 has been used to genetically modify genomes in a variety of species, including non-human primates. Unfortunately, this new technology does cause mosaic mutations, and we do not yet know whether such mutations can functionally disrupt the targeted gene or cause the pathology seen in human disease. Addressing these issues is necessary if we are to generate large animal models of human diseases using...
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