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Article

IL27 exerts a powerful effect on systolic overload-induced cardiac inflammation, fibrosis, and heart failure development

2026-08-11

Abstract excerpt

<h4>BACKGROUND</h4> Interleukin-27 (IL-27) is a heterodimeric cytokine that serves as a bifunctional rheostat rather than an inherently pro- or anti-inflammatory signaling protein. However, the specific role of IL-27 in regulating systolic overload-induced cardiac inflammation and heart failure (HF) pathogenesis remains unknown. <h4>METHODS</h4> We investigated the effects of genetic IL-27 receptor deficiency (I...

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Literature Corpus work
7bc394a5-51d3-5f23-a55e-1dd0a6d16069
DOI
10.64898/2026.08.05.743140
Open publication

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