Article

Targeting the Gαi1/3–Gab1 Axis Enhances BMP2-Mediated Bone Regeneration

2026-02-24

Abstract excerpt

<title>Abstract</title> <p> Background Bone morphogenetic protein 2 (BMP2) is a pivotal cytokine for skeletal formation, homeostasis, and regeneration. While its signaling through serine/threonine kinase receptors (BMPRI/II) and downstream pathways (PI3K-Akt-mTOR, Erk, Smad) is known to drive osteogenesis, the full mechanistic picture remains incomplete. Our prior work identified Gαi1 and Gαi3, inhibitory G pro...

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Literature Corpus work: 7bc10687-5e05-5b9a-898c-0f22294461ad
DOI: 10.21203/rs.3.rs-8866157/v1

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