Osteoblast-Specific Expression of the Fibrous Dysplasia (FD)–Causing Mutation <i>GsαR201C</i> Produces a High Bone Mass Phenotype but Does Not Reproduce FD in the Mouse

Abstract excerpt

We recently reported the generation and initial characterization of the first direct model of human fibrous dysplasia (FD; OMIM #174800), obtained through the constitutive systemic expression of one of the disease-causing mutations, Gsα(R201C) , in the mouse. To define the specific pathogenetic role(s) of individual cell types within the stromal/osteogenic system in FD, we generated mice expressing Gsα(R201C)...

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