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A male infertility mutation reverts NANOS1 activity from anti-apoptotic to pro-apoptotic by disrupting repression of <i>GADD45A</i> , <i>GADD45B</i> , <i>GADD45G</i> and <i>RHOB</i> genes

2019-11-28

Abstract excerpt

<h4>Background</h4> While Nanos-mediated maintenance of germ cells in Drosophila and mice has been related to regulation of apoptosis, the relevance of these findings to human physiology is uncertain. Previously we have described the p.[(Pro34Thr);(Ser83del)] double NANOS1 mutation as associated with an absence of germ cells in the testes of infertile patients. The aim of this study was to identify the mechanis...

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Literature Corpus work
7bb2a087-a66d-5518-a813-0e465fed477a
DOI
10.1101/858654
Open publication

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A male infertility mutation reverts NANOS1 activity from anti-apoptotic to pro-apoptotic by disrupting repression of <i>GADD45A</i> , <i>GADD45B</i> , <i>GADD45G</i> and <i>RHOB</i> genesDOI 10.1101/858654
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