Article

Familial primary ovarian insufficiency associated with a <i>SYCE1</i> point mutation: Defective meiosis elucidated in humanized mice

2020-02-07

Abstract excerpt

<h4>Objective</h4> To investigate if nonsense mutation SYCE1 c.613C˃T - found in women with familial primary ovarian insufficiency (POI)- is actually responsible for infertility, and to elucidate the involved molecular mechanisms. <h4>Design</h4> As most fundamental mammalian oogenesis events occur during the embryonic phase, thus hindering the study of POI’s etiology/pathogeny in infertile women, we have use...

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Literature Corpus work: 773ea9d2-d3e5-5f60-b2d8-279567e69d81
DOI: 10.1101/2020.02.07.938639

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