Article

Bifurcation drives the evolution of assembly-line biosynthesis

2021-06-23

Abstract excerpt

Reprogramming biosynthetic assembly-lines is a topic of intense interest. This is unsurprising as the scaffolds of most antibiotics in current clinical use are produced by such pathways. The modular nature of assembly-lines provides a direct relationship between the sequence of enzymatic domains and the chemical structure of the product, but rational reprogramming efforts have been met with limited success. To gai...

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Literature Corpus work: 7b9ac82e-721f-5eab-8190-0dcc8cafef3f
DOI: 10.1101/2021.06.23.449585

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