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Bifurcation drives the evolution of assembly-line biosynthesis

17 Jun 2022

Abstract excerpt

Reprogramming biosynthetic assembly-lines is a topic of intense interest. This is unsurprising as the scaffolds of most antibiotics in current clinical use are produced by such pathways. The modular nature of assembly-lines provides a direct relationship between the sequence of enzymatic domains and the chemical structure of the product, but rational reprogramming efforts have been met with limited success. To...

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PMID: 35715397
DOI: 10.1038/s41467-022-30950-z

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