Diversity oriented biosynthesis via accelerated evolution of modular gene clusters.

doi:10.1038/s41467-017-01344-3

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Article

Diversity oriented biosynthesis via accelerated evolution of modular gene clusters.

Nature communications - 31 Oct 2017

Wlodek Aleksandra, Kendrew Steve G, Coates Nigel J, Hold Adam, Pogwizd Joanna, Rudder Steven, Sheehan Lesley S, Higginbotham Sarah J, Stanley-Smith Anna E, Warneck Tony, Nur-E-Alam Mohammad, Radzom Markus, Martin Christine J, Overvoorde Lois, Samborskyy Markiyan, Alt Silke, Heine Daniel, Carter Guy T, Graziani Edmund I, Koehn Frank E, McDonald Leonard, Alanine Alexander, Rodríguez Sarmiento Rosa María, Chao Suzan Keen, Ratni Hasane, Steward Lucinda, Norville Isobel H, Sarkar-Tyson Mitali, Moss Steven J, Leadlay Peter F, Wilkinson Barrie, Gregory Matthew A

Abstract excerpt

Erythromycin, avermectin and rapamycin are clinically useful polyketide natural products produced on modular polyketide synthase multienzymes by an assembly-line process in which each module of enzymes in turn specifies attachment of a particular chemical unit. Although polyketide synthase encoding genes have been successfully engineered to produce novel analogues, the process can be relatively slow, inefficient,...

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PMID: 29089518
DOI: 10.1038/s41467-017-01344-3
PMCID: PMC5663706

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