Article

Locating binding sites of the general anaesthetic propofol using photoaffinity labelling

2013-01-01

Abstract excerpt

3-(5’-isopropyl-6’-hydroxyphenyl)-3-trifluoromethyl-diazirine (photofol), a new drug developed in our laboratory, is structurally homologus to the general anaesthetic propofol with one of its isopropyl groups being substituted for a trifluoromethyl-diazirine group. Photofol was shown to act in a similar manner to propofol, albeit with a three-fold reduction in potency on inducing a loss of righting reflex in rats...

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Literature Corpus work: 7b983e10-39ef-584f-9ab3-3fce2b4b05df
DOI: 10.25560/10995

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