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Article

Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol.

Current neuropharmacology - 1 Jan 2016

Eaton Megan M, Germann Allison L, Arora Ruby, Cao Lily Q, Gao Xiaoyi, Shin Daniel J, Wu Albert, Chiara David C, Cohen Jonathan B, Steinbach Joe Henry, Evers Alex S, Akk Gustav

Abstract excerpt

BACKGROUND: Propofol is a sedative agent that at clinical concentrations acts by allosterically activating or potentiating the γ-aminobutyric acid type A (GABAA) receptor. Mutational, modeling, and photolabeling studies with propofol and its analogues have identified potential interaction sites in the transmembrane domain of the receptor. At the &quot;+&quot; of the β subunit, in the β-α interface,...

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Identifiers

PMID: 26830963
DOI: 10.2174/1570159x14666160202121319
PMCID: PMC5050400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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