Article
Characterization of benzodiazepine binding site on human alpha1-acid glycoprotein using flunitrazepam as a photolabeling agent.
Biochimica et biophysica acta - 10 Oct 2005
Chuang Victor Tuan Giam, Hijioka Motoki, Katsuki Masaaki, Nishi Koji, Hara Teppei, Kaneko Ken-ichi, Ueno Megumi, Kuniyasu Akihiko, Nakayama Hitoshi, Otagiri Masaki
Abstract excerpt
The binding of flunitrazepam (FNZP) by human alpha1-acid glycoprotein (hAGP) and the relationships between the extent of drug binding and desialylation and the genetic variants of hAGP were examined. The photolabeling specificity of [3H]FNZP was confirmed by findings in which other hAGP-binding ligands inhibited the formation of covalent bonds between [3H]FNZP and hAGP. The photolabeling of asialo-hAGP suggested...
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