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Article

Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels.

Molecular pharmacology - 1 Nov 2013

Heusser Stephanie A, Howard Rebecca J, Borghese Cecilia M, Cullins Madeline A, Broemstrup Torben, Lee Ui S, Lindahl Erik, Carlsson Jens, Harris R Adron

Abstract excerpt

GABA(A) receptors play a crucial role in the actions of general anesthetics. The recently published crystal structure of the general anesthetic propofol bound to Gloeobacter violaceus ligand-gated ion channel (GLIC), a bacterial homolog of GABA(A) receptors, provided an opportunity to explore str...

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Identifiers

PMID: 23950219
DOI: 10.1124/mol.113.087692
PMCID: PMC3807073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-23950219-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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