Article

<i>bax</i>Deficiency Prevents the Increased Cell Death of Immature Neurons in<i>bcl-x</i>-Deficient Mice

1997-05-01

Abstract excerpt

The intracellular balance between pro- and antiapoptotic members of the Bcl-2 gene family is thought to regulate cell death. Targeted disruption of bcl-x , a death repressing member, causes massive cell death of immature neurons in the developing mouse CNS, whereas targeted disruption of bax , a proapoptotic member, blocks the death of specific populations of sympathetic and motor neurons. In the present study, mi...

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Literature Corpus work: 7b94dc6a-184c-5090-97de-2029158e2e0c
DOI: 10.1523/jneurosci.17-09-03112.1997

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<i>bax</i>Deficiency Prevents the Increased Cell Death of Immature Neurons in<i>bcl-x</i>-Deficient MiceDOI 10.1523/jneurosci.17-09-03112.1997Read

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