Article
Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations.
The European journal of neuroscience - 1 Mar 2000
Middleton G, Cox S W, Korsmeyer S, Davies A M
Abstract excerpt
Bcl-2 and Bax are cytoplasmic proteins that have antagonistic actions on apoptosis. To investigate the extent to which these proteins function independently in regulating neuronal apoptosis, we studied the in vivo and in vitro development of two populations of sensory neurons of mouse embryos that lack one or both proteins. Absence of Bcl-2 increased neuronal apoptosis and reduced the number of neurons in both...
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