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Article

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.

Molecular cell - 1 Dec 2000

Lindsten T, Ross A J, King A, Zong W X, Rathmell J C, Shiels H A, Ulrich E, Waymire K G, Mahar P, Frauwirth K, Chen Y, Wei M, Eng V M, Adelman D M, Simon M C, Ma A, Golden J A, Evan G, Korsmeyer S J, MacGregor G R, Thompson C B

Abstract excerpt

Proapoptotic Bcl-2 family members have been proposed to play a central role in regulating apoptosis. However, mice lacking bax display limited phenotypic abnormalities. As presented here, bak(-/-) mice were found to be developmentally normal and reproductively fit and failed to develop any age-related disorders. However, when Bak-deficient mice were mated to Bax-deficient mice to create mice lacking both genes,...

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Identifiers

PMID: 11163212
DOI: 10.1016/s1097-2765(00)00136-2
PMCID: PMC3057227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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