Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Motor neuron degeneration is attenuated in bax-deficient neurons in vitro.

Journal of neuroscience research - 1 Mar 1999

Bar-Peled O, Knudson M, Korsmeyer S J, Rothstein J D

Abstract excerpt

Apoptosis plays a major role in motor neuron survival during developmental cell death, after axotomy, and in motor neuron diseases. Bax is the first member of the bcl-2 family shown to promote apoptosis. In the present study, we used the bax-deficient mouse model to determine the role of bax in motor neuron survival in vitro by using dissociated spinal cord cultures. This system enables the maturation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to bcl-2-Associated X Protein
Share to Cell Size

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Culture Media, Serum-Free

Share to Kainic Acid

Share to Nerve Degeneration

Share to Paraquat

Share to Superoxides

Source

Identifiers

PMID: 10082077
DOI: 10.1002/(SICI)1097-4547(19990301)55:5<542::AID-JNR2>3.0.CO;2-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Motor neuron degeneration is attenuated in bax-deficient neurons in vitro.PMID 10082077Read ↗

Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS.Semantic proximity Read ↗

Abolishing Bax-Dependent Apoptosis Shows Beneficial Effects on Spinal Muscular Atrophy Model MiceSemantic proximity Read ↗

Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosisSemantic proximity Read ↗

Neuromuscular development in the absence of programmed cell death: phenotypic alteration of motoneurons and muscle.Semantic proximity Read ↗

BCL-2 and BAX Protect Adult Mice from Lethal Sindbis Virus Infection but Do Not Protect Spinal Cord Motor Neurons or Prevent ParalysisSemantic proximity Read ↗

Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice.Semantic proximity Read ↗

Dissociation of Progressive Dopaminergic Neuronal Death and Behavioral Impairments by Bax Deletion in a Mouse Model of Parkinson's DiseasesSemantic proximity Read ↗

Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy.Semantic proximity Read ↗

Development of sensory neurons in the absence of NGF/TrkA signaling in vivo.Semantic proximity Read ↗

The role of apoptosis in neuromuscular diseases and prospects for anti-apoptosis therapy.Semantic proximity Read ↗

Programmed Cell Death in the Developing Nervous SystemSemantic proximity Read ↗

<i>bax</i>Deficiency Prevents the Increased Cell Death of Immature Neurons in<i>bcl-x</i>-Deficient MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.