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Article

Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice.

The Journal of biological chemistry - 4 Jan 2008

Keramaris Elizabeth, Ruzhynsky Vladamir A, Callaghan Steve M, Wong Estelle, Davis Roger J, Flavell Richard, Slack Ruth S, Park David S

Abstract excerpt

Retinoblastoma-deficient mice show massive neuronal damage and deficits in both CNS and PNS tissue. Previous work in the field has shown that death is regulated through distinct processes where CNS tissue undergoes death regulated by the tumor suppressor p53 and the apoptosome component, APAF1. Death in the PNS, however, is independent of p53 and reliant on the death protease, caspase 3. In the present study, we...

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Share to bcl-2-Associated X Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17984095
DOI: 10.1074/jbc.M701552200

Genes

APAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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